General Chemistry Laboratory
(Chem 128L)
Spring Semester 2009
Sulfa-Drugs Resources
This is a separate webpage consisting of resources for the Research Project covering the second half of the Chem128L spring semester General Chemistry Lab Course at Concordia College.
Sulfadrug
Extinction Coefficients
These values are averaged values for the entire class, there are two
sections working on each sulfadrug so values for extinction coefficients
represent an average of all values determined combined. This value should be
used for all future sulfadrug concentration determinations.
The Sulfadrug assignments for each section are given below:
Background reports were compiled by Dr Wyllie and pdfs for each section are available below:
If your report is not here, it was not emailed to me so I could not compile it. If you email it to me, I will add it to the file below so please do so at your earliest convenience
| Day | Time | Instructor | Sulfadrug | |
| Monday | 1:20 - 4:20 pm | Krogstad | Sulfathiazole | here |
| Monday | 6:30 - 9:30 pm | Wyllie | Sulfadiazine | here |
| Tuesday | 9:00 am- 12:00 noon | Jensen | Sulfamethoxazole | here |
| Tuesday | 2:40 - 5:40 pm | Mach | Sulfamethazine | here |
| Tuesday | 6:30 - 9:30 pm | Mork | Sulfamethoxazole | here |
| Wednesday | 2:40 - 5:40 pm | Wyllie | Sulfamethazine | here |
| Thursday | 9:00 am- 12:00 noon | Mach | Sulfathiazole | here |
| Thursday | 1:20 - 4:20 pm | Peterson | Sulfadiazine | here |
Background reports for each section will be compiled and put on this website so when complete, email a copy of the report to me at wyllie@cord.edu
Structures for all 4 sulfadrugs are given below.
Some excellent work on investigating and reducing the levels of antibiotics in Minnesota waters was published by a group at the University of Minnesota. I highly recommend that you read the following material as it provides both inspiration and discusses a number of the experimental aspects of this kind of research. It is also written at a level that is easier perhaps to understand than some of the more technical journal pieces.
Reference Details:
A pdf of the article is available below:
http://www.cura.umn.edu/reporter/05-Spr/Arnold.pdf
(Linked with permission from the Center for Urban and Regional Affairs (CURA), University of Minnesota, www.cura.umn.edu.)
Several interesting observations have also been made available from the data obtained by last years class
1. The upper solubility limit of the sulfadrugs is about 10 mM (25 mg / 10 mL of neutral water) at room temperature.
2. The sulfadrugs absorb from 200 nm – 310 nm. Vis spectroscopy will not work!
3. The sulfadrugs absorb very well. In fact, the solutions only have to have concentrations of about 0.1 mM to give an absorbance of 1-1.5.
Contact wyllie@cord.edu with any questions